kosmanlab Publications in MyBibliography

http://www.ncbi.nlm.nih.gov/sites/myncbi/daniel.kosman.1/bibliography/41141062/public/?sort=date&direction=ascending

Selected publications by research focus

 

Delineating the structure and mechanism of the fungal high-affinity Fe-uptake system

 

This work has informed two significant questions in metallobiology: 1) How do multi-copper oxidases support the electron transfers they catalyze; and 2) How does an aerobic organism manage the complex aqueous and redox chemistry of iron so as to make it available for cell utilization. This work has been supported by an award from NIDDK since 2000, an award that has been acknowledged in 27 primary research papers and 10 review articles. Examples of these publications are:

 

Kosman, D. J.  2010.  Redox cycling in iron uptake, efflux and trafficking. J. Biol. Chem. 285:26729-26735 (refereed MiniSeries Review). PMID:20522542

Kosman, D. J. 2013.  Iron metabolism in aerobes: managing ferric iron hydrolysis and ferrous iron autoxidation.  Coord. Chem. Rev. 257:210-217. PMID:23264695

 

"Multicopper Oxidases” – invited chapter in Metalloprotein Active Site Assembly, Michael K. Johnson, Robert A. Scott, Eds, Wiley, October, 2017. ISBN: 978-1-119-15983-4

  

Iron trafficking across the blood-brain barrier (BBB)

 

McCarthy, R. C., Kosman, D. J. 2015. Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy. Cell. Mol. Life Sci. 72:709-727 PMID:25355056 

 

McCarthy, R. C., Kosman, D. J. 2015. Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier. Front. Mol. Neurosci. 8, 31. PMID: 26236187

  

McCarthy, R. C., Kosman, D. J. 2014.  Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS ONE Feb 12;9(2):e89003 PMID:24533165

 

McCarthy, R. C., Park, Y.H., Kosman, D. J. 2014. sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep. 15:809-815 PMID:24867889

   

Iron uptake and efflux in primary hippocampal neurons

  

Ji, C., Kosman, D.J. 2015. Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons. J. Neurochem. 133:668-683. PMID:25649872

  

APP-dependent iron regulation of brain iron trafficking in physiology and disease

 

McCarthy, R. C., Kosman, D. J. 2015. Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy. Cell. Mol. Life Sci. 72:709-727 PMID:25355056 

  

The research on iron and manganese trafficking in the brain has been supported by both NIDDK and NINDS. Currently support for this work comes from a five-year RO1 award from NINDS, 2017-2022.